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LÉON'S CASE STUDY:

Fibrosarcoma with Typical Features of Postinjection Sarcoma at Site of Microchip Implant in a Dog: Histologic and Immunohistochemical Study.
M. Vascellari, E. Melchiotti and F. Mutinelli.
Istituto Zooprofilattico Sperimentale delle Venezie, Histopathology Department, Viale dell'Universita 10, 35020 Legnaro (PD), Italy.
Vet Pathol 43:545-548 (2006).
This paper was published in Veterinary Pathology regarding Léon’s case. The full text (free) is available online. Click here.

MICROCHIPS - CASE STUDIES:
Electronic Identification, Radio Frequency Identification (RFID), National Animal Identification System (NAIS), Subcutaneous Microchip for Human Identification (SMHId)

DOGS AND CATS

Delayed Spinal Cord Injury Following Microchip Placement in a Dog.
Joslyn SK, Witte PG, Scott HW.
University of Glasgow, Small Animal Hospital, 464 Bearsden Road, Glasgow, Lanarkshire G61 1QH, UK.
Veterinary and Comparative Orthopaedics and Traumatology (VCOT). April 2010; 23(3): 214-217.
www.ncbi.nlm.nih.gov

Fibrosarcoma Adjacent to the Site of Microchip Implantation in a Cat.
Daly MK, Saba CF, Crochik SS, Howerth EW, Kosarek CE, Cornell KK, Roberts RE, Northrup NC.
Comparative Oncology Program, University of Georgia, College of Veterinary Medicine, Athens, GA 30602, USA.
Journal of Feline Medicine & Surgery. April 2008; 10(2): 202-205.
www.ncbi.nlm.nih.gov

Fibrosarcoma with Typical Features of Postinjection Sarcoma at Site of Microchip Implant in a Dog: Histologic and Immunohistochemical Study.
M. Vascellari, E. Melchiotti and F. Mutinelli.
Istituto Zooprofilattico Sperimentale delle Venezie, Histopathology Department, Viale dell'Universita 10, 35020 Legnaro (PD), Italy.
Veterinary Pathology. 2006; 43(4): 545-548.
journals.sagepub.com

Imaging Diagnosis--Spinal Injury Following Aberrant Microchip Implantation.
Hicks DG, Bagley RS.
Washington State University College of Veterinary Medicine, PO Box 647060, Pullman, WA 99164, USA.
Veterinary Radiology and Ultrasound. March-April 2008; 49(2): 152-153.
www.ncbi.nlm.nih.gov

In Vivo Reactions in Mice and In Vitro Reactions in Feline Cells to Implantable Microchip Transponders with Different Surface Materials.
Linder M, DrMedVet[1], Hüther S, DrMedVet[2] and Reinacher M, DrMedVet, DECVP[1].
[1] Institut für Veterinär-Pathologie, Justus-Liebig-Universität Giessen, Frankfurter Strasse 96, 35392 Giessen, Germany.
[2] Schmachtenbergstrasse 20, 45219 Essen, Germany.
The Veterinary Record. 2009; 165(2): 45-49.
veterinaryrecord.bvapublications.com

Liposarcoma at the Site of an Implanted Microchip in a Dog.
Vascellari M, Mutinelli F, Cossettini R, Altinier E.
Istituto Zooprofilattico Sperimentale delle Venezie, Histopathology Department, Viale dell'Universita 10, 35020 Legnaro (PD), Italy.
The Veterinary Journal. Sept 2004; 168(2): 188-190.
www.ncbi.nlm.nih.gov (Abstract)
www.antichips.com (Full Text)

The Summary of: Liposarcoma at the Site of an Implanted Microchip in a Dog (Liposarcoma In Sede Di Applicazione Del Microchip In Un Cane : A.P.I.V. - Associazione Italiana Patologi Veterinari: ATTI del XXI Convegno Nazionale) is available at:
www.aipvet.it

Microchip-Associated Fibrosarcoma in a Cat.
Carminato A, Vascellari M, Marchioro W, Melchiotti E, Mutinelli F. Department of Histopathology, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.
Veterinary Dermatology. 2011; 22(6): 565-569.
www.ncbi.nlm.nih.gov

Spinal Cord Injury Resulting from Incorrect Microchip Placement in a Cat.
Simon Platt BVM&S, Dipl ACVIM (Neurology), Dipl ECVN, MRCVS, Lara Wieczorek DVM, MRCVS, Ruth Dennis MA, VetMB, DVR, Dipl ECVDI, MRCVS and Alberta De Stefani DVM, MRCVS.
Centre for Small Animal Studies, Animal Health Trust, Newmarket, Suffolk CB8 7UU, UK.
Journal of Feline Medicine & Surgery. April 2007; 9(2): 157-160.
www.sciencedirect.com

Surgical Removal of a Microchip from a Puppy's Spinal Canal.
Smith TJ, Fitzpatrick N.
Fitzpatrick Referrals, Halfway Lane, Eashing, Surrey GU7 2QQ, UK.
Veterinary and Comparative Orthopaedics and Traumatology (VCOT). 2009; 22(1): 63-65.
www.ncbi.nlm.nih.gov


MICE AND RATS

A Novel Embryo Identification System by Direct Tagging of Mouse Embryos Using Silicon-Based Barcodes.
Novo S[1], Barrios L[1], Santaló J[1], Gómez-Martinez R[2], Duch M[2], Esteve J[2], Plaza JA[2], Nogués C[1], Ibáñez E[1].
[1]Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain, [2]Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC), Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Human Reproduction. 2011; 26(1): 96-105.
humrep.oxfordjournals.org (Full Text)
humrep.oxfordjournals.org (Full Text)

Alternative Models for Carcinogenicity Testing.
Cohen SM*, Robinson D[1], MacDonald J[2].
*Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, Nebraska 68198-3135; [1] International Life Sciences Institute-Health and Environmental Sciences Institute, 1 Thomas Circle, Suite 900, Washington, District of Columbia 20005; and [2] Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033.
Toxicological Sciences. 2001; 64(1): 14-19.
toxsci.oxfordjournals.org (Note - On page 18 of the Full Text document the authors write: "With respect to the sarcomas, it is important to distinguish between those occurring at the site of transponder implantation [used for identification] versus those that arise at other sites. Those related to transponders may be more likely related to foreign body sarcomagenesis rather than being chemically related.")

CHMP SWP Conclusions and Recommendations on the Use of Genetically Modified Animal Models for Carcinogenicity Assessment.
European Medicines Agency. June 23, 2004. Pages 1-12.
www.ema.europa.eu (Note: See section 3.2.1 Spontaneous Tumour Incidences at the bottom of page 2/12.)

Fibrosarcomas Associated with Passive Integrated Transponder Implants.
T.E. Palmer, J. Nold, M. Palazzolo and T. Ryan.
Covance Laboratories, Inc., Madison, Wisconsin, 53704.
Toxicologic Pathology. 1998; 26: 170.
www.antichips.com

Foreign-Body Tumorigenesis: Sarcomas Induced in Mice by Subcutaneously Implanted Transponders.
Keith A. Johnson.
The Toxicology Research Laboratory, The Dow Chemical Company, Midland MI, 48674.
Veterinary Pathology. 1996; 33(5): 619.
www.antichips.com

In Vivo Reactions in Mice and In Vitro Reactions in Feline Cells to Implantable Microchip Transponders with Different Surface Materials.
Linder M, DrMedVet[1], Hüther S, DrMedVet[2] and Reinacher M, DrMedVet, DECVP[1].
[1] Institut für Veterinär-Pathologie, Justus-Liebig-Universität Giessen, Frankfurter Strasse 96, 35392 Giessen, Germany.
[2] Schmachtenbergstrasse 20, 45219 Essen, Germany.
The Veterinary Record. 2009; 165: 45-49.
veterinaryrecord.bvapublications.com

Microchip-Associated Tumour in a C57/BL Mouse.
GTP Meeting 2000: Case No 15.
www.eurotoxpath.org

Subcutaneous Microchip-Associated Tumours in B6C3F1 Mice: A Retrospective Study to Attempt to Determine their Histogenesis.
Le Calvez S, Perron-Lepage MF, Burnett R.
Ecole Nationale Veterinaire, Unite d'Anatomie Pathologique, 44307 Nantes, France.
Experimental and Toxicologic Pathology. March 2006; 57(4): 255-265.
www.ncbi.nlm.nih.gov (Abstract)
www.antichips.com (Full Text)

Subcutaneous Soft Tissue Tumours at the Site of Implanted Microchips in Mice.
Tillmann T, Kamino K, Dasenbrock C, Ernst H, Kohler M, Morawietz G, Campo E, Cardesa A, Tomatis L, Mohr U.
Institute of Experimental Pathology, Hannover Medical School, Germany.
Experimental and Toxicologic Pathology. Aug 1997; 49(3-4):197-200.
www.ncbi.nlm.nih.gov (Abstract)
www.antichips.com (Full Text)

The Trp53 Hemizygous Mouse in Pharmaceutical Development: Points to Consider for Pathologists.
Floyd E[1], Mann P[2], Long G[3], Ochoa R[4].
[1]Pfizer Nagoya Laboratories, Taketoyo, Aichi, Japan 470-2393, [2]Experimental Pathology Laboratories, Inc., Galena, Maryland Histology and Immunohistochemistry of Seven Ferret Vaccination-site Fibrosarcomas21635, [3]Eli Lilly & Co., Greenfield, Indiana 46140, and [4]Pfizer Groton Laboratories, Groton, Connecticut 06340.
Toxicologic Pathology. Jan-Feb 2002; 30(1): 147-156.
journals.sagepub.com (Note: In the Abstract section on page 147, the authors write: "Use of implanted electronic transponders can increase the incidence of sarcomas.")

Transponder-Induced Sarcoma in the Heterozygous p53+/- Mouse.
Blanchard KT, Barthel C, French JE, Holden HE, Moretz R, Pack FD, Tennant RW, Stoll RE.
Department of Toxicology and Safety Assessment, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877, USA.
Toxicologic Pathology. Sept-Oct 1999; 27(5): 519-527.
www.ncbi.nlm.nih.gov (Abstract)
journals.sagepub.com (Full Text)

Tumors in Long-Term Rat Studies Associated with Microchip Animal Identification Devices.
Elcock LE, Stuart BP, Wahle BS, Hoss HE, Crabb K, Millard DM, Mueller RE, Hastings TF, Lake SG.
Bayer Corporation, Toxicology Department, Stilwell, Kansas 66085, USA.
Experimental and Toxicologic Pathology. Feb 2001; 52(6): 483-491.
www.ncbi.nlm.nih.gov (Abstract)
www.antichips.com (Full Text)


OTHER ANIMALS

Calcinosis Circumscripta in a Common Marmoset (Callithrix Jacchus Jacchus).
Wachtman LM[1], Pistorio AL[2], Eliades S[2], Mankowski JL[1]. [1]Department of Comparative Medicine, [2]Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland.
Journal of the American Association for Laboratory Animal Science (JAALAS). May 2006; 45(3): 54-57.
aalas.publisher.ingentaconnect.com

Microchip-Associated Leiomyosarcoma in an Egyptian Fruit Bat (Rousettus Aegyptiacus).
Jessica Siegal-Willott, D.V.M., Darryl Heard, B.V.M.S., Ph.D., Dipl. A.C.Z.M., Naime Sliess, M.S., Diane Naydan, B. S., and John Roberts, D.V.M., Dipl. A.C.V.P.
From the Departments of Small Animal Clinical Sciences (Siegal-Willott, Heard) and Infectious Diseases and Pathology (Sliess, Roberts), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA; and the Pathology Service, Veterinary Medical Teaching Hospital, University of California–Davis, Davis, California 95616, USA (Naydan).
Journal of Zoo and Wildlife Medicine. June 2007; 38(2): 352-356.
www.ncbi.nlm.nih.gov (Abstract)
www.batconservancy.org (Full Text)

Microchip-Associated Sarcoma in a Shrew (Suncus Murinus).
Schutt LK, Turner PV.
Department of Pathobiology, University of Guelph, Guelph, ON, Canada.
Journal of the American Association for Laboratory Animal Science (JAALAS). Sept 2010; 49(5): 638-641.
www.ncbi.nlm.nih.gov

Microchip Insertion in Alpacas.
van der Burgt G, Dowle M.
The Veterinary Record. 2007; 160(6): 204.
veterinaryrecord.bvapublications.com or web.archive.org (Abstract)

Soft Tissue Sarcomas Associated with Identification Microchip Implants in Two Small Zoo Animals.
Pessier AP, Stalis IH, Sutherland-Smith M, Spelman LH, Montali, RJ.
Proc Amer Assoc Zoo Vet. 1999, Pages 139-140.

Transponder Associated Neoplasia in Damaraland Mole-Rats (Crytomys Damarensis).
Sura R[1], Schwartz DR[1], Goldman BD[2], French RA[3].
[1]Connecticut Veterinary Medical Diagnostic Laboratory, Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, [2]Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT, [3]New Hampshire Veterinary Diagnostic Laboratory, University of New Hampshire, Durham, NH.
Veterinary Pathology. 2009; 46(5): 1043.
vet.sagepub.com (See case number 85 on page 1043.)
journals.sagepub.com (Full Text)


MAGNETIC RESONANCE IMAGING (MRI)

Evaluation of the Susceptibility Artifacts and Tissue Injury Caused by Implanted Microchips in Dogs on 1.5T Magnetic Resonance Imaging.
Saito M, Ono S, Kayanuma H, Honnami M, Muto M, Une Y.
Department of Surgery II, School of Veterinary Medicine, Azabu University.
The Journal of Veterinary Medical Science. 2010; 72(5): 575-581.
www.ncbi.nlm.nih.gov (Abstract)
www.jstage.jst.go.jp (Full Text)


MICROCHIP-SCANNER TECHNOLOGY

In Vitro Sensitivity of Commercial Scanners to Microchips of Various Frequencies.
Lord LK, Pennell ML, Ingwersen W, Fisher RA, Workman JD.
Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Journal of American Veterinary Medical Association. Dec 2008; 233(11): 1723-1728.
www.ncbi.nlm.nih.gov


Sensitivity of Commercial Scanners to Microchips of Various Frequencies Implanted in Dogs and Cats.
Lord LK, Pennell ML, Ingwersen W, Fisher RA.
Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Journal of American Veterinary Medical Association. Dec 2008; 233(11): 1729-1735.
www.ncbi.nlm.nih.gov

MISCELLANEOUS

Electronic Identification with Injectable Transponders in Pig Production: Results of a Field Trail on Commercial Farms and Slaughterhouses Concerning Injectability and Retrievability.
Lambooij E, Langeveld NG, Lammers GH, Huiskes JH.
DLO-Institute for Animal Science and Health, branche Zeist, The Netherlands.
Veterinary Quarterly. Dec 1995; 17(4): 118-123.
www.ncbi.nlm.nih.gov


MICROCHIP-CANCER REPORT:

Microchip-Induced Tumors in Laboratory Rodents and Dogs: A Review of the Literature 1990-2006.
Katherine Albrecht, Ed.D.
November 19, 2007.
www.antichips.com


UNPUBLISHED MEDICAL DATA THAT REFERENCES MICROCHIP IMPLANTS:

Bull Mastiff Develops Hemangiosarcoma: One Microchip Implant Located in Tumour and Another Microchip Implant Located Adjacent to Tumour.
Blue Ridge Veterinary Associates, Purcellville, VA 20132. July 2009.
www.noble-leon.com (X-ray)
This X-ray has been generously provided by Howard Gillis (Seamus' dad) in order to increase awareness of the potential microchip-cancer risk.

Warmblood Mare Experiences Nerve Damage Due to Microchip Implant.
Laarakker EGA, Willekens C, Kelfkens M, Kokke F.
Den Hoek, Bisschopsweg 2, 3732 HW De Bilt, The Netherlands. June 2005.
web.archive.org (Original Dutch veterinary report)
web.archive.org (English translation)

Yorkshire Terrier Develops Epitheliotropic Lymphoma at Site of Microchip Implant.
McGee ED.
Antec Diagnostics, Southhaven, MS 38671. December 2009.
www.noble-leon.com (Biopsy Report)
This medical report has been graciously provided by Linda Hawkins (Scotty's mom) for the website of Noble-Leon.com in order to increase awareness of the potential microchip-cancer risk.

Last Updated: June 2017